The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance

Abstract excerpt

The papain superfamily member bleomycin hydrolase (Blmh) is a neutral cysteine protease with structural similarity to a 20S proteasome. Bleomycin (BLM), a clinically used glycopeptide anticancer agent, is deaminated in vitro by Blmh. We used gene targeting to generate mice that lack Blmh and demonstrated that Blmh is the sole enzyme required for BLM deamination. Although some Blmh null mice were viable and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to NF-κB Signaling Pathways
• Share to Peptidase Inhibition and Analysis
• Share to Ubiquitin and proteasome pathways