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Article

Novel autoregulatory function of hepatitis B virus M protein on surface gene expression.

The Journal of biological chemistry - 29 Jul 2005

Huang Tsurng-Juhn, Lu Cheng-Chan, Tsai Jui-Chen, Yao Wei-Jen, Lu Xuanyong, Lai Ming-Derg, Liu Hsiao-Sheng, Shiau Ai-Li

Abstract excerpt

The hepatitis B virus surface gene consists of a single open reading frame divided into three coding regions: pre-S1, pre-S2, and S. By alternate translation at each of the three initiation codons, L, M, and S proteins can be synthesized. Studies have shown that M protein is not essential for viral replication, virion morphogenesis, or in vitro infectivity. In this study, we show that native M protein can...

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Identifiers

PMID: 15899887
DOI: 10.1074/jbc.M502209200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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