Article
The N-Terminus Makes the Difference: Impact of Genotype-Specific Disparities in the N-Terminal Part of The Hepatitis B Virus Large Surface Protein on Morphogenesis of Viral and Subviral Particles.
Cells - 13 Aug 2020
Jiang Bingfu, Wen Xingjian, Wu Qingyan, Bender Daniela, Carra Gert, Basic Michael, Kubesch Alica, Peiffer Kai-Henrik, Boller Klaus, Hildt Eberhard
Abstract excerpt
The N-terminus of the hepatitis B virus (HBV) large surface protein (LHB) differs with respect to genotypes. Compared to the amino terminus of genotype (Gt)D, in GtA, GtB and GtC, an additional identical 11 amino acids (aa) are found, while GtE and GtG share another similar 10 aa. Variants of GtB and GtC affecting this N-terminal part are associated with hepatoma formation. Deletion of these amino-terminal 11 aa...
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