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Article

Recombination at long mutant telomeres produces tiny single- and double-stranded telomeric circles.

Molecular and cellular biology - 1 Jun 2005

Groff-Vindman Cindy, Cesare Anthony J, Natarajan Shobhana, Griffith Jack D, McEachern Michael J

Abstract excerpt

Recombinational telomere elongation (RTE) known as alternate lengthening of telomeres is the mechanism of telomere maintenance in up to 5 to 10% of human cancers. The telomeres of yeast mutants lacking telomerase can also be maintained by recombination. Previously, we proposed the roll-and-spread model to explain this elongation in the yeast Kluveromyces lactis. This model suggests that a very small (...

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Identifiers

PMID: 15899847
DOI: 10.1128/MCB.25.11.4406-4412.2005
PMCID: PMC1140610

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Recombination at long mutant telomeres produces tiny single- and double-stranded telomeric circles.PMID 15899847Read ↗

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