Article
Factors influencing the recombinational expansion and spread of telomeric tandem arrays in Kluyveromyces lactis.
Eukaryotic cell - 1 Oct 2003
Natarajan Shobhana, Groff-Vindman Cindy, McEachern Michael J
Abstract excerpt
We have previously shown that DNA circles containing telomeric repeats and a marker gene can promote the recombinational elongation of telomeres in Kluyveromyces lactis by a mechanism proposed to involve rolling-circle DNA synthesis. Wild-type cells acquire a long tandem array at a single telomere, while telomerase deletion (ter1-delta) cells, acquire an array and also spread it to multiple telomeres. In this...
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