Article
Template requirements for telomerase translocation in Kluyveromyces lactis.
Molecular and cellular biology - 1 Jan 2004
Underwood Dana H, Zinzen Robert P, McEachern Michael J
Abstract excerpt
Telomeres are synthesized by telomerase, a specialized reverse transcriptase, which contains a template in its intrinsic RNA component. In Kluyveromyces lactis, the repeats synthesized by the wild-type telomerase are 25 nucleotides (nt) in length and uniform in sequence. To determine the role of the 5-nt repeats defining the ends of the K. lactis telomerase RNA template in telomerase translocation, we have made...
Topics
- Base Pair Mismatch
- Base Sequence
- Biological Transport, Active
- DNA, Bacterial
- Genes, Bacterial
- Kluyveromyces
- Molecular Sequence Data
- Mutation
- RNA, Bacterial
- Telomerase
- Terminal Repeat Sequences