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Article

Telomere loops and homologous recombination-dependent telomeric circles in a Kluyveromyces lactis telomere mutant strain.

Molecular and cellular biology - 1 Jan 2008

Cesare Anthony J, Groff-Vindman Cindy, Compton Sarah A, McEachern Michael J, Griffith Jack D

Abstract excerpt

The Kluyveromyces lactis ter1-16T strain contains mutant telomeres that are poorly bound by Rap1, resulting in a telomere-uncapping phenotype and significant elongation of the telomeric DNA. The elongated telomeres of ter1-16T allowed the isolation and examination of native yeast telomeric DNA by electron microscopy. In the telomeric DNA isolated from ter1-16T, looped molecules were observed with the physical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17967889
DOI: 10.1128/MCB.01122-07
PMCID: PMC2223312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Telomere loops and homologous recombination-dependent telomeric circles in a Kluyveromyces lactis telomere mutant strain.PMID 17967889Read ↗

Telomerase, the recombination machinery and Rap1 play redundant roles in yeast telomere protection.Semantic proximity Read ↗

Recombination at long mutant telomeres produces tiny single- and double-stranded telomeric circles.Semantic proximity Read ↗

Telomere fusions caused by mutating the terminal region of telomeric DNA.Semantic proximity Read ↗

Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination.Semantic proximity Read ↗

TER1, the RNA subunit of fission yeast telomerase.Semantic proximity Read ↗

Factors influencing the recombinational expansion and spread of telomeric tandem arrays in Kluyveromyces lactis.Semantic proximity Read ↗

Recombinational telomere elongation promoted by DNA circles.Semantic proximity Read ↗

Dynamics of telomeric DNA turnover in yeast.Semantic proximity Read ↗

Maintenance of very long telomeres by recombination in the Kluyveromyces lactis stn1-M1 mutant involves extreme telomeric turnover, telomeric circles, and concerted telomeric amplification.Semantic proximity Read ↗

Mutant telomeric repeats in yeast can disrupt the negative regulation of recombination-mediated telomere maintenance and create an alternative lengthening of telomeres-like phenotype.Semantic proximity Read ↗

A mutation in the STN1 gene triggers an alternative lengthening of telomere-like runaway recombinational telomere elongation and rapid deletion in yeast.Semantic proximity Read ↗

Mutant telomeres inhibit transcriptional silencing at native telomeres of the yeast Kluyveromyces lactis.Semantic proximity Read ↗

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