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Article

Runaway telomere elongation caused by telomerase RNA gene mutations.

Nature - 3 Aug 1995

McEachern M J, Blackburn E H

Abstract excerpt

The ribonucleoprotein enzyme telomerase adds telomeric DNA onto chromosome ends and is normally regulated so that telomeric DNA lengths are kept within defined bounds. In the telomerase RNA gene from the yeast Kluyveromyces lactis, specific mutations that alter telomeric DNA sequences result in t...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
Conserved Sequence
DNA Nucleotidylexotransferase
DNA Replication
DNA, Fungal
Genes, Fungal
Kluyveromyces
Models, Genetic
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

RNA, Fungal

Repetitive Sequences, Nucleic Acid

Telomere

Source

Identifiers

PMID: 7630414
DOI: 10.1038/376403a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7630414-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Runaway telomere elongation caused by telomerase RNA gene mutations.PMID 7630414Read ↗

Dynamics of telomeric DNA turnover in yeast.Semantic proximity Read ↗

Recombination at long mutant telomeres produces tiny single- and double-stranded telomeric circles.Semantic proximity Read ↗

Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.Semantic proximity Read ↗

Template requirements for telomerase translocation in Kluyveromyces lactis.Semantic proximity Read ↗

Telomerase, the recombination machinery and Rap1 play redundant roles in yeast telomere protection.Semantic proximity Read ↗

How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasisSemantic proximity Read ↗

DNA:RNA hybrids at telomeres – when it is better to be out of the (R) loopSemantic proximity Read ↗

The telomere and telomerase: how do they interact?Semantic proximity Read ↗

Mutant telomeric repeats in yeast can disrupt the negative regulation of recombination-mediated telomere maintenance and create an alternative lengthening of telomeres-like phenotype.Semantic proximity Read ↗

When Telomerase Causes Telomere Loss.Semantic proximity Read ↗

A mutation in the STN1 gene triggers an alternative lengthening of telomere-like runaway recombinational telomere elongation and rapid deletion in yeast.Semantic proximity Read ↗

Telomere fusions caused by mutating the terminal region of telomeric DNA.Semantic proximity Read ↗

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