Article
Functional modification of dendritic cells with recombinant adenovirus encoding interleukin 10 for the treatment of sepsis.
Shock (Augusta, Ga.) - 1 Jun 2005
Oberholzer Andreas, Oberholzer Caroline, Efron Philip A, Scumpia Philip O, Uchida Takefumi, Bahjat Keith, Ungaro Ricardo, Tannahill Cynthia L, Murday Michelle, Bahjat Frances R, Tsai Van, Hutchins Beth, Moldawer Lyle L, Laface Drake, Clare-Salzler Michael J
Abstract excerpt
Control of dendritic cell (DC) function is critical for strategies to modulate innate and acquired immune responses. We examined whether transduction of murine DCs with adenoviral vectors (Adv) expressing interleukin (IL)-10 could alter their phenotype and T cell stimulatory function. Murine bone marrow-derived DCs were transduced with AdV encoding human IL-10 or green fluorescent protein (GFP). Whereas...
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