Article
Dendritic cells transfected with adenoviral vectors as vaccines.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Senesac Joseph, Gabrilovich Dmitry, Pirruccello Samuel, Talmadge James E
Abstract excerpt
Dendritic cells (DCs) are critical to the initiation of a T-cell response. They constitute the most potent antigen-presenting cell (APC) endowed with the unique capacity to stimulate an antigen-specific T-cell responses by naïve T cells. Adenoviruses (Ad) have high transduction efficiency for many cell types including cells of hematopoietic origin independent of their mitotic status, and replication-defective Ad...
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