Article
Epigenetic regulation of the dendritic cell-marker gene ADAM19.
Biochemical and biophysical research communications - 1 Jul 2005
Ehrnsperger Achim, Rehli Michael, Thu-Hang Pham, Kreutz Marina
Abstract excerpt
Human ADAM19 (MADDAM) is a molecular marker for human dendritic cells and not expressed in macrophages. To investigate its cell-type-specific expression, we defined the transcriptional start site and the proximal promoter. Sequence analysis of the promoter revealed putative binding sites for several transcription factors including Sp1, Sp3, NF-kappaB, and VDR. A minimal promoter construct of 150 bp showed little...
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