Article
AP-1 activated by toll-like receptors regulates expression of IL-23 p19.
The Journal of biological chemistry - 4 Sept 2009
Liu Weicheng, Ouyang Xinshou, Yang Jianjun, Liu Jianguo, Li Qingshan, Gu Yongpeng, Fukata Masayuki, Lin Tony, He John Cijiang, Abreu Maria, Unkeless Jay C, Mayer Lloyd, Xiong Huabao
Abstract excerpt
Interleukin (IL)-23, a new member of the IL-12 family, plays a central role in the Th17 immune response and in autoimmune diseases. It is clear that activated macrophages and dendritic cells produce IL-23, but the molecular mechanisms whereby inflammatory signals stimulate IL-23 expression are not fully understood. We demonstrate that induction of IL-23 p19 gene expression by LPS depends on the TLR4 and MyD88...
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