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Article

Transcriptional Regulation of CHI3L1, a Marker Gene for Late Stages of Macrophage Differentiation

1 Nov 2003

Abstract excerpt

The protein product of the CHI3L1 gene, human cartilage 39-kDa glycoprotein (HC-gp39), is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. In contrast to many other monocyte/macrophage markers, its expression is absent in monocytes and strongly induced during late stages of human macrophage differentiation. To gain insights into the molecular mechanisms underlying its cell...

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PMID: 12933821
DOI: 10.1074/jbc.m306792200

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