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Article

2.3 Å Crystal Structure of Tetanus Neurotoxin Light Chain<sup>,</sup>

27 Apr 2005

Abstract excerpt

TeNT is the causative agent of the neuroparalytic disease tetanus. A key component of TeNT is its light chain, a Zn(2+) endopeptidase that targets SNAREs. Recent structural studies of closely related BoNT endopeptidases indicate that substrate-binding exosites remote from a conserved active site are the primary determinants of substrate specificity. Here we report the 2.3 A X-ray crystal structure of TeNT-LC,...

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PMID: 15895988
DOI: 10.1021/bi050262j

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