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Crystal structures of OrfX1 , OrfX2 and the OrfX1 – OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1

19 Jan 2023

Abstract excerpt

Botulinum neurotoxins (BoNTs) are among the most lethal toxins known to humans, comprising seven established serotypes termed BoNT/A-G encoded in two types of gene clusters (ha and orfX) in BoNT-producing clostridia. The ha cluster encodes four non-toxic neurotoxin-associated proteins (NAPs) that assemble with BoNTs to protect and enhance their oral toxicity. However, the structure and function of the orfX-type...

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PMID: 36653893
DOI: 10.1002/1873-3468.14576

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