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Article

Substrate specific metabolism by polymorphic cytochrome P450 2D6 alleles.

Toxicology in vitro : an international journal published in association with BIBRA - 1 Aug 2005

Bogni Alessia, Monshouwer Mario, Moscone Anna, Hidestrand Mats, Ingelman-Sundberg Magnus, Hartung Thomas, Coecke Sandra

Abstract excerpt

A comparative metabolism study was performed for bufuralol, dextromethorphan, imipramine, mianserin, sparteine, tamoxifen, haloperidol and two drug candidates (Rec27/0110 and Rec15/2739) on V79 cells genetically engineered to express human cytochrome P450 (CYP) variants 2D6*1, 2D*2, 2D*9 and 2D*17. Unexpectedly, the CYP2D6*17 dependent metabolism profile of haloperidol and Rec27/0110 were found to differ from all...

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Identifiers

PMID: 15893449
DOI: 10.1016/j.tiv.2005.04.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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