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V79 Chinese hamster cells genetically engineered for polymorphic cytochrome P450 2D6 and their predictive value for humans.

ALTEX - 1 Jan 2003

Krebsfaenger Niels, Mürdter Thomas E, Zanger Ulrich M, Eichelbaum Michel F, Doehmer Johannes

Abstract excerpt

With more than 30 genetic variants human cytochrome P450 2D6 (CYP2D6) presents the most extensive variation among all cytochromes P450. At the same time, roughly 30% of all drugs are metabolised by CYP2D6. Therefore, V79 Chinese hamster cells were genetically engineered for the genetic variants *...

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PMID: 12947487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12947487-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

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