Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution.

doi:10.1186/gb-2006-7-8-R69

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Article

Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution.

Genome biology - 1 Jan 2006

Tischler Julia, Lehner Ben, Chen Nansheng, Fraser Andrew G

Abstract excerpt

BACKGROUND: Systematic analyses of loss-of-function phenotypes have been carried out for most genes in Saccharomyces cerevisiae, Caenorhabditis elegans, and Drosophila melanogaster. Although such studies vastly expand our knowledge of single gene function, they do not address redundancy in genetic networks. Developing tools for the systematic mapping of genetic interactions is thus a key step in exploring the...

Topics

Animals
Caenorhabditis elegans
Evolution, Molecular
Genes, Duplicate
Models, Genetic
Phenotype
RNA Interference

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Identifiers

PMID: 16884526
DOI: 10.1186/gb-2006-7-8-R69
PMCID: PMC1779603

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