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Article

Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans.

Genetics - 1 Jul 2011

Sawyer Jacob M, Glass Stephanie, Li Trudy, Shemer Gidi, White Noor D, Starostina Natalia G, Kipreos Edward T, Jones Corbin D, Goldstein Bob

Abstract excerpt

Morphogenesis is an important component of animal development. Genetic redundancy has been proposed to be common among morphogenesis genes, posing a challenge to the genetic dissection of morphogenesis mechanisms. Genetic redundancy is more generally a challenge in biology, as large proportions of the genes in diverse organisms have no apparent loss of function phenotypes. Here, we present a screen designed to...

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Identifiers

PMID: 21527776
DOI: 10.1534/genetics.111.129486
PMCID: PMC3176534

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