Article
Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes.
Diabetologia - 1 Sept 2010
Crawford S A, Costford S R, Aguer C, Thomas S C, deKemp R A, DaSilva J N, Lafontaine D, Kendall M, Dent R, Beanlands R S B, McPherson R, Harper M-E
Abstract excerpt
AIMS/HYPOTHESIS: AMP-activated protein kinase (AMPK) has a broad role in the regulation of glucose and lipid metabolism making it a promising target in the treatment of type 2 diabetes mellitus. We therefore sought to characterise for the first time the effects of chronic AMPK activation on skeletal muscle carbohydrate metabolism in carriers of the rare gain-of-function mutation of the gene encoding AMPKgamma(3)...
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