Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The influence of hippocampal dopamine D2 receptor losses on episodic-memory decline across 5 years is moderated by BDNF and KIBRA polymorphisms.

Cortex; a journal devoted to the study of the nervous system and behavior - 1 Jul 2024

Papenberg Goran, Karalija Nina, Johansson Jarkko, Andersson Micael, Axelsson Jan, Riklund Katrine, Lindenberger Ulman, Nyberg Lars, Bäckman Lars

Abstract excerpt

Losses in dopamine (DA) functioning may contribute to aging-related decline in cognition. Hippocampal DA is necessary for successful episodic memory formation. Previously, we reported that higher DA D2 receptor (D2DR) availability in hippocampus is beneficial for episodic memory only in older carriers of more advantageous genotypes of well-established plasticity-related genetic variations, the brain-derived...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain-Derived Neurotrophic Factor
Share to Hippocampus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Longitudinal Studies

Share to Memory Disorders

Share to Memory, Episodic

Share to Neuropsychological Tests

Share to Receptors, Dopamine D2

Source

Identifiers

PMID: 38749085
DOI: 10.1016/j.cortex.2024.01.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The influence of hippocampal dopamine D2 receptor losses on episodic-memory decline across 5 years is moderated by BDNF and KIBRA polymorphisms.PMID 38749085Read ↗

Dopamine and glutamate receptor genes interactively influence episodic memory in old age.Semantic proximity Read ↗

Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory.Semantic proximity Read ↗

The DRD2 Taq1A A1 Allele May Magnify the Risk of Alzheimer's in Aging African-Americans.Semantic proximity Read ↗

Interactive effects of KIBRA and CLSTN2 polymorphisms on episodic memory in old-age unipolar depression.Semantic proximity Read ↗

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases.Semantic proximity Read ↗

Overestimation of the effects of the BDNF val66met polymorphism on episodic memory-related hippocampal function: a critique of a recent meta-analysis.Semantic proximity Read ↗

Rare genetic coding variants associated with age-related episodic memory decline implicate distinct memory pathologies in the hippocampusSemantic proximity Read ↗

KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.Semantic proximity Read ↗

Cortisol awakening response and Val66Met BDNF polymorphism interact to shape verbal fluency in aging.Semantic proximity Read ↗

DRD2 C957T polymorphism is associated with improved 6-month verbal learning following traumatic brain injury.Semantic proximity Read ↗

Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans.Semantic proximity Read ↗

Impact of KIBRA Polymorphism on Memory Function and the Hippocampus in Older Adults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.