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Article

Genetic variation of the serotonin 2a receptor affects hippocampal novelty processing in humans.

PloS one - 18 Jan 2011

Schott Björn H, Seidenbecher Constanze I, Richter Sylvia, Wüstenberg Torsten, Debska-Vielhaber Grazyna, Schubert Heike, Heinze Hans-Jochen, Richardson-Klavehn Alan, Düzel Emrah

Abstract excerpt

Serotonin (5-hydroxytryptamine, 5-HT) is an important neuromodulator in learning and memory processes. A functional genetic polymorphism of the 5-HT 2a receptor (5-HTR2a His452Tyr), which leads to blunted intracellular signaling, has previously been associated with explicit memory performance in several independent cohorts, but the underlying neural mechanisms are thus far unclear. The human hippocampus plays a...

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Identifiers

PMID: 21267461
DOI: 10.1371/journal.pone.0015984
PMCID: PMC3022731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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