Article
Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts.
Neurobiology of disease - 1 Nov 2005
Sawa Akira, Nagata Eiichiro, Sutcliffe Siobhan, Dulloor Pratima, Cascio Matthew B, Ozeki Yuji, Roy Sophie, Ross Christopher A, Snyder Solomon H
Abstract excerpt
Accumulation of mutant Huntingtin (Htt), especially the N-terminal-cleaved Htt, participates in the pathophysiology of Huntington's disease (HD). It is difficult to elucidate temporal properties of the translocation of "endogenous" Htt using autopsy HD patient brains. Thus, we examined the cell biology of "endogenous" Htt cleavage and nuclear translocation in cultured lymphoblasts of HD patients and controls....
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