Article
In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.
Human molecular genetics - 1 Jan 1999
Hackam A S, Singaraja R, Zhang T, Gan L, Hayden M R
Abstract excerpt
A unifying feature of the CAG expansion diseases is the formation of intracellular aggregates composed of the mutant polyglutamine-expanded protein. Despite the presence of aggregates in affected patients, the precise relationship between aggregates and disease pathogenesis is unresolved. Results...
Topics
- Amino Acid Sequence
- Base Sequence
- Biological Transport
- Brain
- Cell Line
- Cell Nucleus
- Cytoplasm
- DNA, Complementary
- Humans
- Huntingtin Protein
- Huntington Disease
- In Vitro Techniques
- Macromolecular Substances
- Models, Biological
- Mutation
- Nerve Tissue Proteins
- Nuclear Localization Signals
- Nuclear Proteins