Isolation of Telomerelike Sequences from Cryptococcus neoformans and Their Use in High-Efficiency Transformation

Abstract excerpt

Development of a transformation system for the fungal human pathogen Cryptococcus neoformans is an important prerequisite for the identification of genes involved in virulence. It has previously been reported that low-efficiency transformation can be achieved by using the cloned C. neoformans URA5 gene and ura5 mutants. The introduction of linearized URA5 vectors into C. neoformans resulted in unstable...

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