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Article

A genomic safe haven for mutant complementation in Cryptococcus neoformans.

PloS one - 1 Jan 2015

Arras Samantha D M, Chitty Jessica L, Blake Kirsten L, Schulz Benjamin L, Fraser James A

Abstract excerpt

Just as Koch's postulates formed the foundation of early infectious disease study, Stanley Falkow's molecular Koch's postulates define best practice in determining whether a specific gene contributes to virulence of a pathogen. Fundamentally, these molecular postulates state that if a gene is involved in virulence, its removal will compromise virulence. Likewise, its reintroduction should restore virulence to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25856300
DOI: 10.1371/journal.pone.0122916
PMCID: PMC4391909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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