Article
Genetic association, post-translational modification, and protein-protein interactions in Type 2 diabetes mellitus.
Molecular & cellular proteomics : MCP - 1 Aug 2005
Sharma Amitabh, Chavali Sreenivas, Mahajan Anubha, Tabassum Rubina, Banerjee Vijaya, Tandon Nikhil, Bharadwaj Dwaipayan
Abstract excerpt
Type 2 diabetes mellitus is a complex disorder with a strong genetic component. Inherited complex disease susceptibility in humans is most commonly associated with single nucleotide polymorphisms. The mechanisms by which this occurs are still poorly understood. Here we focus on analyzing the effect of a set of disease-causing missense variations of the monogenetic form of Type 2 diabetes mellitus and a set of...
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