Article
CD4 T cells in murine acquired immunodeficiency syndrome: polyclonal progression to anergy.
The Journal of experimental medicine - 1 Jun 1992
Muralidhar G, Koch S, Haas M, Swain S L
Abstract excerpt
We have examined the kinetics of changes that occur in the helper T cell subset during murine acquired immunodeficiency syndrome, which occurs after infection with the mix of viruses known as BM5. We find that there is expansion of the CD4 T cells by 2 wk, 50% of the CD4 T cells become large as the disease progresses, and the CD4 T cell population is increasingly comprised of cells with a memory/activated...
Topics
- Animals
- Antibodies, Monoclonal
- Antigen-Presenting Cells
- CD4 Antigens
- Cell Line
- Cells, Cultured
- Flow Cytometry
- Interferon-gamma
- Interleukins
- Kinetics
- Lymphocyte Activation