Article
Longitudinal changes in CD4+ T cell antigen receptor diversity and naive/memory cell phenotype during 9 to 26 months of antiretroviral therapy of HIV-infected patients.
AIDS research and human retroviruses - 20 Nov 2000
Gea-Banacloche J C, Martino L, Mican J M, Hallahan C W, Baseler M, Stevens R, Lambert L, Polis M, Lane H C, Connors M
Abstract excerpt
Although skewing of the CD4+ TCR repertoire in advanced HIV infection is well documented, increases in polyclonality during antiretroviral therapy have been less consistently observed. Ten patients, each with documented abnormalities within the CD4+ TCR repertoire, were studied by CDR3 spectratyping, semiquantitative PCR, and SSCP during 9-26 months of therapy. Naive and memory cell phenotypes were analyzed by...
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