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Article

Evidence for the HIV-1 phenotype switch as a causal factor in acquired immunodeficiency.

Nature medicine - 1 Mar 1998

Glushakova S, Grivel J C, Fitzgerald W, Sylwester A, Zimmerberg J, Margolis L B

Abstract excerpt

Both cellular and humoral immunodeficiency develop in vivo after prolonged infection with HIV-1, but the mechanisms are unclear. Initial infection with HIV-1 is transmitted by macrophage (M)-tropic/non-syncytia-inducing (NSI) viruses, which hyperactivate the immune system, and, in one view, cause immunodeficiency by "exhaustion" of lymphoid tissue. An alternative hypothesis is that immunodeficiency is caused by...

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Identifiers

PMID: 9500611
DOI: 10.1038/nm0398-346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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