Article
An extended tyrosine-targeting motif for endocytosis and recycling of the dense-core vesicle membrane protein phogrin.
Traffic (Copenhagen, Denmark) - 1 Jun 2005
Wasmeier Christina, Burgos Patricia V, Trudeau Tammy, Davidson Howard W, Hutton John C
Abstract excerpt
Integral membrane proteins of neuroendocine dense-core vesicles (DCV) appear to undergo multiple rounds of exocytosis; however, their trafficking and site of incorporation into nascent DCVs is unclear. Previous studies with phogrin (IA-2beta) identified sorting signals in the luminal domain that is cleaved post-translationally; we now describe an independent DCV targeting motif in the cytosolic domain that may...
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