Article
Extremely skewed X-chromosome inactivation patterns in women with recurrent spontaneous abortion.
The Australian & New Zealand journal of obstetrics & gynaecology - 1 Oct 2006
Bagislar Sevgi, Ustuner Isik, Cengiz Bora, Soylemez Feride, Akyerli Cemaliye Boylu, Ceylaner Serdar, Ceylaner Gulay, Acar Aynur, Ozcelik Tayfun
Abstract excerpt
BACKGROUND: The role of extremely skewed X-chromosome inactivation (XCI) has been questioned in the pathogenesis of recurrent spontaneous abortion (RSA) but the results obtained were conflicting. AIMS: We therefore investigated the XCI patterns in peripheral blood DNA obtained from 80 patients who had RSA and 160 age-matched controls. METHODS: Pregnancy history, age, karyotype, and disease information was...
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