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Article

Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase.

The Journal of biological chemistry - 8 Jul 2005

Arnold Jamie J, Vignuzzi Marco, Stone Jeffrey K, Andino Raul, Cameron Craig E

Abstract excerpt

The kinetic, thermodynamic, and structural basis for fidelity of nucleic acid polymerases remains controversial. An understanding of viral RNA-dependent RNA polymerase (RdRp) fidelity has become a topic of considerable interest as a result of recent experiments that show that a 2-fold increase in fidelity attenuates viral pathogenesis and a 2-fold decrease in fidelity reduces viral fitness. Here we show that a...

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Identifiers

PMID: 15878882
DOI: 10.1074/jbc.M503444200
PMCID: PMC1557591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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