Article
Structural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase.
The Journal of biological chemistry - 26 Dec 2014
Moustafa Ibrahim M, Korboukh Victoria K, Arnold Jamie J, Smidansky Eric D, Marcotte Laura L, Gohara David W, Yang Xiaorong, Sánchez-Farrán María Antonieta, Filman David, Maranas Janna K, Boehr David D, Hogle James M, Colina Coray M, Cameron Craig E
Abstract excerpt
RNA viruses encoding high- or low-fidelity RNA-dependent RNA polymerases (RdRp) are attenuated. The ability to predict residues of the RdRp required for faithful incorporation of nucleotides represents an essential step in any pipeline intended to exploit perturbed fidelity as the basis for rational design of vaccine candidates. We used x-ray crystallography, molecular dynamics simulations, NMR spectroscopy, and...
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