Article
PDZ interactions regulate rapid turnover of the scaffolding protein EBP50 in microvilli.
The Journal of cell biology - 23 Jul 2012
Garbett Damien, Bretscher Anthony
Abstract excerpt
Scaffolding proteins containing PDZ (postsynaptic density 95/discs large/zonula occludens-1) domains are believed to provide relatively stable linkages between components of macromolecular complexes and in some cases to bridge to the actin cytoskeleton. The microvillar scaffolding protein EBP50 (ERM-binding phosphoprotein of 50 kD), consisting of two PDZ domains and an ezrin-binding site, retains specific...
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