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Article

Subclonal TP53 mutations are frequent and predict resistance to radioimmunotherapy in follicular lymphoma.

Blood advances - 12 Sept 2023

Burack W Richard, Li Hongli, Adlowitz Diana, Spence Janice M, Rimsza Lisa M, Shadman Mazyar, Spier Catherine M, Kaminski Mark S, Leonard John P, Leblanc Michael L, Smith Sonali M, Friedberg Jonathan W

Abstract excerpt

Although TP53 is commonly mutated in transformed follicular lymphoma, mutations are reported in <5% of pretreatment follicular lymphoma (FL) specimens. We assayed archival follicular B-cell non-Hodgkin lymphoma specimens from a completed clinical trial, Southwest Oncology Group S0016, a phase 3 randomized intergroup trial of CHOP (cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisone) chemotherapy plus...

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Identifiers

PMID: 37379264
DOI: 10.1182/bloodadvances.2022009467
PMCID: PMC10471938

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