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Article

PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases.

Genes and immunity - 1 Oct 2005

Gomez L M, Anaya J-M, Gonzalez C I, Pineda-Tamayo R, Otero W, Arango A, Martín J

Abstract excerpt

A functional single nucleotide polymorphism (SNP) C1858T in the protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene encoding an intracellular phosphatase with negative regulatory effects on T-cell activation is associated with some autoimmune diseases in Caucasians. Taking into account firstly, that SNP frequencies may vary across populations and, secondly, that replication studies are important to confirm...

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Share to Lupus Erythematosus, Systemic

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

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Source

Identifiers

PMID: 16163373
DOI: 10.1038/sj.gene.6364261

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases.PMID 16163373Read ↗

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The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysis.Semantic proximity Read ↗

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Genetic Polymorphism of PTPN22 in Autoimmune Diseases: A Comprehensive Review.Semantic proximity Read ↗

The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.Semantic proximity Read ↗

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