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Article

PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases.

Genes and immunity - 1 Oct 2005

Gomez L M, Anaya J-M, Gonzalez C I, Pineda-Tamayo R, Otero W, Arango A, Martín J

Abstract excerpt

A functional single nucleotide polymorphism (SNP) C1858T in the protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene encoding an intracellular phosphatase with negative regulatory effects on T-cell activation is associated with some autoimmune diseases in Caucasians. Taking into account firs...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lupus Erythematosus, Systemic

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

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Source

Identifiers

PMID: 16163373
DOI: 10.1038/sj.gene.6364261

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16163373-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases.PMID 16163373Read ↗

The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population.Semantic proximity Read ↗

Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus.Semantic proximity Read ↗

Protein tyrosine phosphatase non-receptor type 22 (PTPN22) +1858 C>T gene polymorphism in Egyptian cases with rheumatoid arthritis.Semantic proximity Read ↗

The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysis.Semantic proximity Read ↗

The +1858C/T PTPN22 gene polymorphism confers genetic susceptibility to rheumatoid arthritis in Mexican population from the Western Mexico.Semantic proximity Read ↗

Genetic Polymorphism of PTPN22 in Autoimmune Diseases: A Comprehensive Review.Semantic proximity Read ↗

The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.Semantic proximity Read ↗

Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population.Semantic proximity Read ↗

Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases.Semantic proximity Read ↗

1858 C/T polymorphism of the protein tyrosine phosphatase nonreceptor 22 gene and rheumatoid arthritis risk in europeans: a meta-analysis.Semantic proximity Read ↗

Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.Semantic proximity Read ↗

The functional PTPN22 C1858T polymorphism confers risk for rheumatoid arthritis in patients from Central Mexico.Semantic proximity Read ↗

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