Article
Two inducible, functional cyclooxygenase-2 genes are present in the rainbow trout genome.
Journal of cellular biochemistry - 15 Dec 2007
Ishikawa Tomo-o, Herschman Harvey R
Abstract excerpt
The cyclooxygenases (Cox) catalyze the initial reactions in prostanoid biosynthesis, and produce the common prostanoids precursor, PGH(2). Mammalian species have two Cox isoforms; constitutively expressed cyclooxygenase-1 (Cox-1) and inducible cyclooxygenase-2 (Cox-2). Database searches suggest three Cox genes are present in many fish species. In this study, we cloned and characterized a second Cox-2 cDNA,...
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