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Article

Misregulation of 2 microm circle copy number in a SUMO pathway mutant.

Molecular and cellular biology - 1 May 2005

Chen Xiaole L, Reindle Alison, Johnson Erica S

Abstract excerpt

Attachment of the ubiquitin-like protein SUMO to other proteins is an essential process in Saccharomyces cerevisiae. However, yeast mutants lacking the SUMO ligases Siz1 and Siz2/Nfi1 are viable, even though they show dramatically reduced levels of SUMO conjugation. This siz1Delta siz2Delta double mutant is cold sensitive and has an unusual phenotype in that it forms irregularly shaped colonies that contain...

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Identifiers

PMID: 15870299
DOI: 10.1128/MCB.25.10.4311-4320.2005
PMCID: PMC1087719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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