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Article

The 2 microm plasmid causes cell death in Saccharomyces cerevisiae with a mutation in Ulp1 protease.

Molecular and cellular biology - 1 May 2005

Dobson Melanie J, Pickett Andrew J, Velmurugan Soundarapandian, Pinder Jordan B, Barrett Lori A, Jayaram Makkuni, Chew Joyce S K

Abstract excerpt

The 2 microm circle plasmid confers no phenotype in wild-type Saccharomyces cerevisiae but in a nib1 mutant, an elevated plasmid copy number is associated with cell death. Complementation was used to identify nib1 as a mutant allele of the ULP1 gene that encodes a protease required for removal of a ubiquitin-like protein, Smt3/SUMO, from protein substrates. The nib1 mutation replaces conserved tryptophan 490 with...

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Identifiers

PMID: 15870298
DOI: 10.1128/MCB.25.10.4299-4310.2005
PMCID: PMC1087720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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