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Article

Elucidation of the relationship between enzyme activity and internal motion using a lysozyme stabilized by cavity-filling mutations.

Cellular and molecular life sciences : CMLS - 1 May 2005

Yoshida Y, Ohkuri T, Kino S, Ueda T, Imoto T

Abstract excerpt

We investigated the activity and the internal motions of a stabilized mutant hen lysozyme (HEL) in which the residues M12 and L56 were mutated to L and F, respectively (LF mutant HEL). The result of the activity measurements against glycol chitin at various temperatures suggested that the temperature dependence of the activity of LF mutant HEL shifted to the high-temperature side compared with that of wild-type...

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Identifiers

PMID: 15868103
DOI: 10.1007/s00018-005-5053-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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