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Article

Glycerol-induced folding of unstructured disulfide-deficient lysozyme into a native-like conformation.

Biopolymers - 1 Aug 2009

Sakamoto Keiko, Hirai Ken-Ichi, Kitamura Yoshiaki, Yamazaki Kouta, Yusa Mitsunobu, Tokunaga Naoki, Doi Gakuji, Noda Yasuo, Tachibana Hideki, Segawa Shin-Ichi

Abstract excerpt

2SS[6-127,64-80] variant of lysozyme which has two disulfide bridges, Cys6-Cys127 and Cys64-Cys80, and lacks the other two disulfide bridges, Cys30-Cys115 and Cys76-Cys94, was quite unstructured in water, but a part of the polypeptide chain was gradually frozen into a native-like conformation with increasing glycerol concentration. It was monitored from the protection factors of amide hydrogens against H/D...

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PMID: 19353641
DOI: 10.1002/bip.21198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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