Article
Dynamic structure of human lysozyme derived from X-ray crystallography: normal mode refinement.
Biophysical chemistry - 1 May 1994
Kidera A, Matsushima M, Go N
Abstract excerpt
X-ray crystallography provides a wealth of information about the dynamic as well as static protein structure. A new method of dynamic structure refinement of protein X-ray crystallography, normal mode refinement, is proposed. In this method, the Debye-Waller factor is expanded in terms of the low-frequency internal normal modes and external normal modes, whose amplitudes and couplings are optimized in the process...
Topics
- Crystallography, X-Ray
- Humans
- Models, Molecular
- Muramidase
- Mutation
- Protein Conformation
- Thermodynamics