The role of backbone flexibility in the accommodation of variants that repack the core of T4 lysozyme.

doi:10.1126/science.8259514

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Article

The role of backbone flexibility in the accommodation of variants that repack the core of T4 lysozyme.

Science (New York, N.Y.) - 10 Dec 1993

Baldwin E P, Hajiseyedjavadi O, Baase W A, Matthews B W

Abstract excerpt

To understand better how the packing of side chains within the core influences protein structure and stability, the crystal structures were determined for eight variants of T4 lysozyme, each of which contains three to five substitutions at adjacent interior sites. Concerted main-chain and side-ch...

Topics

Bacteriophage T4
Crystallography, X-Ray
Muramidase
Mutagenesis
Mutation
Protein Conformation
Protein Structure, Secondary
Structure-Activity Relationship

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