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Article

The role of backbone flexibility in the accommodation of variants that repack the core of T4 lysozyme.

Science (New York, N.Y.) - 10 Dec 1993

Baldwin E P, Hajiseyedjavadi O, Baase W A, Matthews B W

Abstract excerpt

To understand better how the packing of side chains within the core influences protein structure and stability, the crystal structures were determined for eight variants of T4 lysozyme, each of which contains three to five substitutions at adjacent interior sites. Concerted main-chain and side-chain displacements, with movements of helical segments as large as 0.8 angstrom, were observed. In contrast, the angular...

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Source

Identifiers

PMID: 8259514
DOI: 10.1126/science.8259514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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