Article
Evolution of resistance mutations pattern in HIV-1-infected patients during intensification therapy with a boosted protease inhibitor.
AIDS (London, England) - 20 May 2005
Blanco José L, Biglia M Alejandra, Arnedo Mireia, Martínez Esteban, Mallolas Josep, Milinkovic Ana, Laguno Montserrat, Larrousse Maria, Leon Agathe, Lonca Montserrat, García Felipe, Miró José M, Pumarola Tomás, Gatell José M
Abstract excerpt
Intensification therapy adding a boosted protease inhibitor (PI) to a failing regimen has the potential to worsen the resistance profile. Sixty-six patients included in four different boosted PI intensification studies were assessed and resistance mutations in the reverse transcriptase and protease genes were evaluated at baseline and 4 weeks after the initiation of the intensification strategy. Only one of the...
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