Article
Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy.
Antimicrobial agents and chemotherapy - 1 Apr 2002
Kantor Rami, Fessel W Jeffrey, Zolopa Andrew R, Israelski Dennis, Shulman Nancy, Montoya Jose G, Harbour Michael, Schapiro Jonathan M, Shafer Robert W
Abstract excerpt
In order to track the evolution of primary protease inhibitor (PI) resistance mutations in human immunodeficiency virus type 1 (HIV-1) isolates, baseline and follow-up protease sequences were obtained from patients undergoing salvage PI therapy who presented initially with isolates containing a single primary PI resistance mutation. Among 78 patients meeting study selection criteria, baseline primary PI...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.