Article
A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women.
Fertility and sterility - 1 May 2005
Walch Katharina, Nagele Friedrich, Zeillinger Robert, Vytiska-Binstorfer Elisabeth, Huber Johannes C, Hefler Lukas A
Abstract excerpt
A common -1607 GG/G polymorphism of the matrix metalloproteinase-1 (MMP1) gene promoter was investigated in a series of Caucasian women with polycystic ovary syndrome (PCOS) and controls, by direct sequencing. In this prospective case-control study, the odds for women with at least one mutant GG allele of the MMP1 promoter to be diagnosed with PCOS was 2.7.
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