Article
[(TTTTA), polymorphism in the promoter of the CYP11A1 gene in the pathogenesis of polycystic ovary syndrome].
Casopis lekaru ceskych - 1 Jan 2010
Prazáková Silvie, Vanková Markéta, Bradnová Olga, Lukásová Petra, Vcelák Josef, Dvoráková Katerina, Vondra Karel, Vrbíková Jana, Bendlová Bela
Abstract excerpt
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrinopathy which is characterized by ovarian androgen excess. PCOS has a strong genetic component but the pathogenetic mechanisms responsible for hyperandrogenemia are still unknown. The CYP11A1 encodes the cholesterol side-chain cleava...
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