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Article

Pregnane X receptor polymorphism affects CYP3A4 induction via a ligand-dependent interaction with steroid receptor coactivator-1.

Pharmacogenetics and genomics - 1 May 2007

Lim Yun-Ping, Huang Jin-Ding

Abstract excerpt

BACKGROUND: The human pregnane X receptor is a ligand-dependent transcription factor that plays critical roles in regulating detoxification genes such as CYP3A4 by recruiting transcriptional coactivators such as steroid receptor coactivator-1 in a ligand-dependent manner. In a previous study (Pharmacogenetics and Genomics 2005, 15: 337-341), we reported a novel pregnane X receptor single nucleotide polymorphism,...

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Identifiers

PMID: 17429319
DOI: 10.1097/FPC.0b013e32803e40d7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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