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Article

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.

The Journal of biological chemistry - 1 Jul 2005

Yang Chengfeng, Liu Ying, Leskow Federico Coluccio, Weaver Valerie M, Kazanietz Marcelo G

Abstract excerpt

beta2-Chimerin is a member of the "non-protein kinase C" intracellular receptors for the second messenger diacylglycerol and the phorbol esters that is yet poorly characterized, particularly in the context of signaling pathways involved in proliferation and cancer progression. beta2-Chimerin possesses a C-terminal Rac-GAP (GTPase-activating protein) domain that accelerates the hydrolysis of GTP from the Rac...

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PMID: 15863513
DOI: 10.1074/jbc.M411629200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.PMID 15863513Read ↗

Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor.Semantic proximity Read ↗

Identification of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac-GAP alpha2-chimaerin.Semantic proximity Read ↗

A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation.Semantic proximity Read ↗

Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling.Semantic proximity Read ↗

Tyrosine phosphorylation of beta2-chimaerin by Src-family kinase negatively regulates its Rac-specific GAP activity.Semantic proximity Read ↗

Reversion of RhoC GTPase-induced inflammatory breast cancer phenotype by treatment with a farnesyl transferase inhibitor.Semantic proximity Read ↗

T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells.Semantic proximity Read ↗

Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication.Semantic proximity Read ↗

Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains.Semantic proximity Read ↗

The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins.Semantic proximity Read ↗

Characterization of the Interaction of Phorbol Esters with the C1 Domain of MRCK (Myotonic Dystrophy Kinase-related Cdc42 Binding Kinase) α/βSemantic proximity Read ↗

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